If a global pandemic is a sign about the end times, then Jesus could've returned during the
Antonine Plague: A.D. 165-180
Which may have been smallpox.
Plague of Cyprian: A.D. 250-271
a bishop of Carthage (a city in Tunisia) who described the epidemic as signaling the
end of the world, the Plague of Cyprian is estimated to have killed 5,000 people a day in Rome alone.
https://www.livescience.com/worst-epidemics-and-pandemics-in-history.html
Plague of Justinian: A.D. 541-542
Some estimates suggest that up to 10% of the world's population died.
https://www.livescience.com/worst-epidemics-and-pandemics-in-history.html
6. The Black Death: 1346-1353
Some estimates suggest that it wiped out over half of Europe's population.
Cocoliztli epidemic: 1545-1548
The
infection that caused the cocoliztli epidemic was a form of viral hemorrhagic fever that killed 15 million inhabitants of Mexico and Central America.
American Plagues: 16th century
The American Plagues are a cluster of Eurasian diseases brought to the Americas by European explorers. These illnesses, including smallpox, contributed to the collapse of the Inca and Aztec civilizations. Some estimates suggest that 90% of the indigenous population in the Western Hemisphere was killed off.
https://www.livescience.com/worst-epidemics-and-pandemics-in-history.html
Great Plague of London: 1665-1666
By the time the plague ended, about 100,000 people, including 15% of the population of London, had died
Great Plague of Marseille: 1720-1723
Plague spread quickly, and over the next three years, as many as 100,000 people may have died in Marseille and surrounding areas. It's estimated that up to 30% of the population of Marseille may have perished
Russian plague: 1770-1772
In plague-ravaged Moscow, the terror of quarantined citizens erupted into violence. Riots spread through the city and culminated in the murder of Archbishop Ambrosius, who was encouraging crowds not to gather for worship (sound familiar?)
By the time the plague ended, as many as 100,000 people may have died. Even after the plague ended, Catherine struggled to restore order. In 1773, Yemelyan Pugachev, a man who claimed to be Peter III (Catherine's executed husband), led an insurrection that resulted in the deaths of thousands more.
https://www.livescience.com/worst-epidemics-and-pandemics-in-history.html
Philadelphia yellow fever epidemic: 1793
Mosquitos.
By the end, more than 5,000 people had died.
Flu pandemic: 1889-1890
In the modern industrial age, new transport links made it easier for influenza viruses to wreak havoc. In just a few months, the disease spanned the globe, killing 1 million people. It took just five weeks for the epidemic to reach peak mortality.
The earliest cases were reported in Russia. The virus spread rapidly throughout St. Petersburg before it quickly made its way throughout Europe and the rest of the world, despite the fact that air travel didn't exist yet.
American polio epidemic: 1916
A polio epidemic that started in New York City caused 27,000 cases and 6,000 deaths in the United States. The disease mainly affects children and sometimes leaves survivors with permanent disabilities.
Polio epidemics occurred
sporadically in the United States until the Salk vaccine was developed in 1954.
Spanish Flu: 1918-1920
An estimated 500 million people from the South Seas to the North Pole fell victim to Spanish Flu.
Asian Flu: 1957-1958
The Asian Flu pandemic was another global showing for influenza. With its roots in China, the disease claimed more than 1 million lives. The virus that caused the pandemic was a blend of avian flu viruses.
AIDS pandemic and epidemic: 1981-present day (because we have no cure yet)
AIDS has claimed an estimated 35 million lives {gay and straight} since it was first identified.
H1N1 Swine Flu pandemic: 2009-2010
The 2009 swine flu pandemic was caused by a new strain of H1N1 that originated in Mexico in the spring of 2009 before spreading to the rest of the world. In one year, the virus infected as many as 1.4 billion people across the globe and killed between 151,700 and 575,400 people, according to the
CDC.
West African Ebola epidemic: 2014-2016
Ebola ravaged West Africa between 2014 and 2016, with 28,600 reported cases and 11,325 deaths. There is no known cure.
Source
He didn't return then, so I don't believe that just because the world is going through a pandemic or a crisis, it necessarily means that Jesus is going to return.
It does mean that people have a tendency to believe that the world is ending when things get rough. Don't worry guys, we've been through this before, and we'll get through it again.
Ecclesiastes 1:9
What has been will be again,
what has been done will be done again;
there is nothing new under the sun.